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[29] Nicotine may result in arousal and wakefulness, mainly via incitement in the basal forebrain

Noteworthy, rat models tend to develop many aspects related to MS when treated with arsenic, including insulin resistance, proatherogenic dyslipidemia, non-alcoholic liver steatosis, heart damage and hypertension, while mouse models seem to develop glucose intolerance and beta cell failure, without developing dyslipidemia and insulin resistance ( Table 1 )